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Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Message from the Vice Chair

"We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research 

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Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs.

Research Areas

Affiliated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Access Research Resources

Recent Publications

Weight and Blood-Based Markers of Cachexia Predict Disability, Hospitalization and Worse Survival in Cancer Immunotherapy Patients.

Tran SD, Forrest NJ, Guggilla V, Perottino GM, Johnson JL, Sosman J, Roy I, Walunas TL.

J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13685. doi: 10.1002/jcsm.13685.

Genomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei.

Felicelli C, Lu X, Coty-Fattal Z, Feng Y, Yin P, Schipma MJ, Kim JJ, Jennings LJ, Bulun SE, Wei JJ.

J Pathol. 2025 Feb;265(2):211-225. doi: 10.1002/path.6379. Epub 2024 Dec 18.

Recommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype.

Kibbi N, Owen JL, Worley B, Alam M; Extramammary Paget's Disease Guideline Study Group.

J Am Acad Dermatol. 2025 Feb;92(2):261-268. doi: 10.1016/j.jaad.2024.07.1531. Epub 2024 Oct 12.

Genetic counseling for the dystrophinopathies-Practice resource of the National Society of Genetic Counselors.

Pickart AM, Martin AS, Gross BN, Dellefave-Castillo LM, McCallen LM, Nagaraj CB, Rippert AL, Schultz CP, Ulm EA, Armstrong N.

J Genet Couns. 2025 Feb;34(1):e1892. doi: 10.1002/jgc4.1892. Epub 2024 Apr 29.

AASLD Practice Guideline on imaging-based noninvasive liver disease assessment of hepatic fibrosis and steatosis.

Sterling RK, Duarte-Rojo A, Patel K, Asrani SK, Alsawas M, Dranoff JA, Fiel MI, Murad MH, Leung DH, Levine D, Taddei TH, Taouli B, Rockey DC.

Hepatology. 2025 Feb 1;81(2):672-724. doi: 10.1097/HEP.0000000000000843. Epub 2024 Mar 15.

Clinical Validation of MyProstateScore 2.0 Testing Using First-Catch, Non-DRE Urine.

Tosoian JJ, Zhang Y, Meyers JI, Heaton S, Siddiqui J, Xiao L, Assani KD, Barocas DA, Ross AE, Chopra Z, Herron GC, Edelson JA, Graham NJ, Singhal U, Salami SS, Morgan TM, Palapattu GS, Wei JT, Chinnaiyan AM.

J Urol. 2025 Jan 21:101097JU0000000000004421. doi: 10.1097/JU.0000000000004421. Online ahead of print.

Targeting allograft inflammatory factor-1 reprograms kidney macrophages to enhance repair.

Husain I, Shah H, Jordan CZ, Natesh NR, Fay OK, Chen Y, Privratsky JR, Kitai H, Souma T, Varghese S, Howell DN, Thorp EB, Luo X.

J Clin Invest. 2025 Jan 21:e185146. doi: 10.1172/JCI185146. Online ahead of print.

Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells.

Wang CA, Hou YC, Hong YK, Tai YJ, Shen C, Hou PC, Fu JL, Wu CL, Cheng SM, Hwang DY, Su YY, Shan YS, Tsai SJ.

Mol Cancer. 2025 Jan 18;24(1):25. doi: 10.1186/s12943-024-02207-4.

Individualized transfusion decisions to minimize adverse cardiovascular outcomes in patients with acute myocardial infarction and anemia.

Portela GT, Ducrocq G, Bertolet M, Alexander JH, Goodman SG, Glynn S, Strom JB, Swanson SA, Lemesle G, Rao SV, Tessalee M, Polonsky TS, Goldfarb M, Traverse JH, Uhl L, Herbert BM, Silvain J, Carson JL, Brooks MM; MINT Trial Investigators.

Am Heart J. 2025 Jan 16:S0002-8703(25)00009-2. doi: 10.1016/j.ahj.2025.01.009. Online ahead of print.

Genetic Variants Associated with the Biochemical Response to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis.

Best CM, Li X, Rotter JI, Prince DK, Hsu S, Hoofnagle AN, Siscovick D, Taylor KD, Williams K, Michos ED, Psaty BM, Shea S, Rice KM, Watson KE, Allen NB, Tracy RP, Robinson-Cohen C, de Boer IH, Kestenbaum BR.

J Clin Endocrinol Metab. 2025 Jan 16:dgaf025. doi: 10.1210/clinem/dgaf025. Online ahead of print.

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